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Brock Purdys 5 TDs leads 49ers to 48-27 win over Colts

Three Things We Learned From the 49ers' Win Against the Colts

A few things were revealed about the 49ers from their win against the Colts that only bode well when the playoffs arrive.

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Five Takeaways From the 49ers’ Win Over the Colts

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Colts playoff hopes facing after loss to 49ers, 'find a way' to win

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49ers 48-27 Colts (Dec 22, 2025) Video Highlights - ESPN

How did the Lions, Bucs, Ravens and Colts end up outside the playoff field heading into Week 17?

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San Francisco 49ers vs Indianapolis Colts recap today: Purdy's huge night buries Colts

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49ers vs. Colts MNF Highlights: Purdy's Career Night, Rivers Pick-6 Sinks Indy

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Brock Purdy's career-high five TD passes power 49ers past Philip Rivers' Colts on 'Monday Night Football'

Purdy finished 25 of 34 for 295 yards, five touchdowns and one interception, becoming the first 49ers quarterback with a five-touchdown passing performance since Hall of Famer Steve Young threw a Supe...

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Monday Night Football predictions, picks, odds for Colts vs 49ers game

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49ers thrash Colts behind Purdy’s 5 TD passes: Live updates and reaction from NFL ‘Monday Night Football’

6 49ers make NFC roster for 2026 Pro Bowl Games

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Niners Wire on MSN · 12h

6 49ers make the NFC roster for the 2026 Pro Bowl Games

The San Francisco 49ers have had a strong showing in 2025, leading to _ of their players getting selected to the 2026 Pro Bowl Games.

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Ravens, Broncos, 49ers and Seahawks Lead the Way With 6 Players Selected to Pro Bowl

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Who made the 2025 Pro Bowl? NFL reveals AFC, NFC rosters

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2026 Pro Bowl roster snubs: Who should be an NFL all-star?

There are always a few standout NFL players who should make the Pro Bowl but aren't named to the initial AFC and NFC rosters.

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Ravens, Broncos, 49ers y Seahawks lideran con seis jugadores seleccionados al Pro Bowl

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Kansas City Chiefs' 2026 Pro Bowl selections are just another reflection of the problems that sunk their season

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Six Seattle Seahawks selected to Pro Bowl Games

Rashid Shaheed, Jaxon Smith-Njigba, Devon Witherspoon and Leonard Williams were selected as starters.

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Broncos have 6 players elected to 2026 Pro Bowl, tied for most in NFL

NFL · 12h

2026 Pro Bowl Games: Complete AFC roster revealed

Latest on 49ers TE George Kittle's injured ankle

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49ers' George Kittle Updates Injury, Feels He Got Hurt on Illegal Hip-Drop Tackle

San Francisco 49ers star tight end George Kittle suffered an ankle injury in Monday night's 48-27 win over the Indianapolis Colts, and he feels that an illegal hip-drop tackle technique was to blame.

Niners Wire on MSN · 5h

49ers avoided disaster with George Kittle's injury

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Source: 49ers' George Kittle has mid to low ankle sprain

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49ers’ George Kittle avoids worst-case scenario with ‘mid-to-low’ ankle sprain

On Monday evening, the San Francisco 49ers continued their winning ways with a blowout 48-27 road win over the Indianapolis Colts.

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Former Hawkeye George Kittle exits Colts game early with ankle injury

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George Kittle receives injury update amid 49ers' push for NFC's No. 1 seed

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George Kittle injury update: 49ers TE gets injury diagnosis from ESPN insider

According to ESPN's Jeremy Fowler, Kittle is dealing with an ankle sprain, described as mid-to-low.

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49ers star tight end George Kittle reportedly has ‘mid-to-low' ankle sprain

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NFL Facing Punishment Decision After George Kittle Injury Claim

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The 49ers have their sights set on the No. 1 seed

The San Francisco 49ers responded to clinching a playoff spot with a 48–27 victory over the Indianapolis Colts. The performance was the most complete showing fr

Why Jeff Saturday believes 49ers will clinch NFC's No. 1 seed in NFL playoffs

ESPN NFL analyst Jeff Saturday explained why he picks the San Francisco 49ers to earn the NFC'S No. 1 seed with two weeks left in the regular season.

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Predicting NFL No. 1 Seeds for NFC, AFC Playoffs with Two Games Left After 49ers' Win

With Week 16 in the books, a bit more clarity has been brought to the 2026 NFL Playoff picture. The bracket is far from set, however, even with 14 teams officially eliminated from contention with two games left to play.

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Near 'perfect' Purdy, 49ers put Colts on brink of playoff elimination

Brock Purdy threw a career-high five scores to carry the San Francisco 49ers past the Indianapolis Colts, whose playoff hopes are now dwindling.

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The most surprising aspect of the 49ers dominating Week 16 win

Brock Purdy was expected to have a big game for the San Francisco 49ers against the Indianapolis Colts. The Colts were missing multiple cornerbacks and their pa

Pat McAfee hails Brock Purdy as ‘remarkable' after 49ers QB destroys his Colts

ESPN host Pat McAfee praised Brock Purdy's "remarkable" performance in the San Francisco 49ers' win over the Indianapolis Colts on Monday night.