When the San Francisco 49ers take on the Seattle Seahawks this Saturday night, Christian McCaffrey will have the chance to accomplish something no running back has ever done. McCaffrey, the 2023 Offensive Player of the Year,

San Francisco 49ers running back Christian McCaffrey can really impact a game, and he's already getting into Mike Macdonald's head.

The couple announced the news in a joint Instagram post featuring black-and-white photos of themselves with the baby moments after she was born. Shortly after, Culpo shared several color photos from the day on her Instagram Stories, sharing that childbirth was “the scariest and most rewarding of all experiences.”

On the field, the guy that will be tasked with actually tackling McCaffrey most often is middle linebacker Ernest Jones IV. While Macdonald deserves a lot of the credit, Jones has played a major role in slowing CMC down since getting traded from Tennessee to Seattle midway through the 2024 campaign.

The San Francisco 49ers received a timely boost as they prepare for a critical showdown against the Seattle Seahawks. With playoff positioning and NFC West stakes looming, all eyes were on Christian McCaffrey’s status after his name surfaced on the injury report earlier this week.

Left tackle Trent Williams has missed practice this week with a hamstring injury and has been listed as questionable to play. Tight end George Kittle (ankle) has the same designation, but said this week that he plans to play after missing Week 17’s win over the Bears.

After being limited to just four games last season due to multiple injuries, McCaffrey has returned to top form in 2025. He’s played in all 16 games for the Niners this term, producing 303 carries for 1,179 yards and 10 touchdowns. He’s also caught 96 passes for 890 yards and seven receiving TDs.

San Francisco 49ers RB Christian McCaffrey, OL Austen Pleasants, DL Alfred Collins, and LB Tatum Bethune shared their thoughts on the season finale vs. the Seahawks, reflected on the team's locked-in mindset,