The antimalarial drug mefloquine could help treat genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, as well as some cancers. In these diseases, a mutation in the genetic code ...

Purpose. The pharmacokinetics of amino-glycosides in patients with chronic spinal cord injury (SCI) is reviewed. Conclusion. Determining appropriate aminoglycoside dosage in patients with SCI is ...

The antimalarial drug mefloquine could help treat genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, as well as some cancers. In these diseases, a mutation in the genetic code ...

ABSTRACT: The nephrotoxicity of gentamicin and amikacin was evaluated comparatively in young and adult rats. The aminoglycosides were administered once daily for 14 days, gentamicin in a dose of ...

Researchers conducted a study to assess the safety and efficacy of aminoglycosides or polymyxin monotherapy for the treatment of adults with complicated urinary tract infections caused by extensively ...

Kidney Failure Risk, Ammonia Excretion Linked These factors include a history of heart failure, which was associated with 3-fold increased odds of acute kidney injury. A history of heart failure is ...

Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then target HCs remains ...

Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging because of the emergence of antibiotic-resistant bacteria. Aminoglycosides, as broad-spectrum antibiotics, ...

Sanofi has taken in-house an early-stage antibiotics program developed by its partner Warp Drive Bio. The novel aminoglycosides were discovered using Warp Drive’s genome mining technology, which ...

Because of the physiological changes in the SCI population, differences in drug pharmacokinetic parameters, and difficulties in assessing renal function in these patients, dosing aminoglycosides in ...