The amyloid cascade hypothesis that deposition of Aβ ... higher Aβ and tau levels in human cerebrospinal fluid and animal model brains. Glymphatic clearance is slower during wakefulness versus ...

Stopping Alzheimer’s ‘dominoes’ from falling The amyloid cascade hypothesis, the prevailing theory of Alzheimer’s disease development, can be compared to a row of dominoes. If amyloid ...

The amyloid cascade hypothesis, the prevailing theory of Alzheimer's disease development, can be compared to a row of dominoes. If amyloid plaques can be cleared from the brain before they trigger ...

By the early 1990s, the amyloid cascade hypothesis had emerged, proposing that AD is fundamentally caused by deposition of Aβ protein. The cascade component of the hypothesis captures the idea ...

In Alzheimer's disease (AD), amyloid β-protein (Aβ ... Can soluble Aβ oligomers trigger a pro-inflammatory cascade by directly or indirectly activating local microglia and astrocytes, and ...