called amyloid precursor protein, into smaller pieces, one of which is amyloid beta. Previous work by the research team had ...

Researchers have dosed the first participant in a clinical trial of an investigational medicine designed to lower the amount ...

And though drugs that have some effect on Alzheimer’s disease, dementia’s most common manifestation, have recently been assessed in America and Britain, not everyone is convinced. The European Union’s ...

The paper T. Liu et al., “The amyloid precursor protein is a conserved Wnt receptor,” eLife, 10:e69199, 2021. Amyloid precursor protein, which generates amyloid-β when broken down, has long been ...

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein ... shown to achieve gene silencing in the ...

Dismissal of long-standing Alzheimer's research ignores the voices of those who matter most: patients, caregivers and doctors.

Goldstein and his colleagues studied the role of amyloid precursor protein (APP), which gives rise to the abnormal ... To complement the mouse studies, the researchers studied the effects of various ...

In the 1980s, researchers studying the autopsied brains of people with Alzheimer’s discovered that they were clogged with sticky plaques made from beta amyloid proteins and toxic tangles made of ...

Genetics researchers studied eFAD families to discover the three known genes that cause familial AD: amyloid precursor protein (APP), presenilin-1 (PS1 ... Tests can determine which gene is at fauly ...

In all samples, microglia were spotted encircling remnants of Aβ plaques, while expressing abundant TREM2, ApoE, SPP1, and complement, to name a few proteins ... after amyloid removal to determine ...

An illustration depicts cells in an Alzheimer’s-affected brain, with abnormal levels of beta amyloid protein clumping together to form plaques that collect between neurons and disrupt cell function.