They demonstrated that a fragment of the amyloid ... pathway for maintaining healthy neurons." The new study further supports that the APP-CTFs resulting from suppressing gamma-secretase might ...

In Alzheimer's disease (AD), amyloid β-protein (Aβ ... allosteric modulators of γ-secretase and Aβ-degrading proteases can all reduce oligomeric Aβ, consequent neuronal degeneration and ...

They discovered that these mutations seemed to prevent gamma-secretase from efficiently cutting amyloid precursor protein ...

However, some of the most popular targets, such as γ-secretase, which has a key role in processing the amyloid precursor protein (APP) to form Aβ, have presented considerable challenges owing to ...