Takeaway Giant axonal neuropathy (GAN) is a progressive neurodegenerative disorder. It develops from a genetic mutation that causes your nerve cells to stop functioning.

More information: Ryosuke Tsuchimochi et al, Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain, Stem Cell Reports (2023). DOI: 10.1016/j.stemcr.2023.02.012 ...

Diffuse axonal injury (DAI) is a severe type of traumatic brain injury. Learn more about DAI, including its symptoms and grading.

Additional authors: Libak Abou, Daniel Whibley, and Anna L. Kratz from the Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan as ...

Giant axonal neuropathy is a rare, autosomal recessive, pediatric, polysymptomatic, neurodegenerative disorder caused by biallelic loss-of-function variants in GAN, the gene encoding gigaxonin.We c ...