Caption The complement membrane attack complex is a pore that inserts into the cell membrane. The complex is formed by up to 18 C9 subunits (purple), the C5, C6, and C7 subunits (various shades of ...

The cleavage of C5 into fragments C5a and C5b is a critical event during the complement cascade, as C5a is a potent pro-inflammatory anaphylatoxin capable of inducing cell migration, adhesion and ...

and the membrane attack complex (complement)—with just a single sub-retinal injection. This innovative approach stands in contrast to existing FDA-approved anti-complement therapies for GA ...

In recent years, the complement system has been implicated in the pathophysiology and progression of many disorders, notably modulating inflammation and causing endothelial and organ damage 1.