Creatinine clearance was 50 ml per minute. The serum albumin concentration was 3.2 gm per 100 ml, and the globulin fraction was 3.6 gm per 100 ml. The serum alkaline phosphatase was 12 Bodansky units.

Forty-eight patients with multiple myeloma, most of them ambulatory outpatients, at 5 co-operating hospitals,‡ were treated. Patients were entered in the double-blind study by randomized card ...