Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions. But previously, astonishingly little was known about how they exactly do that. Researchers ...
More than 44% of individuals receiving high doses of prolonged glucocorticoid medication develop osteonecrosis, with the femoral head being the most commonly affected site, predominantly in those aged ...
A team from the UB has described for the first time the molecular self-assembly process of this key protein and has revealed how its active conformation differs from the traditional model accepted for ...
Glucocorticoid receptors (GRs) are ligand-activated transcription factors that play a pivotal role in mediating the effects of endogenous and synthetic glucocorticoids. These receptors regulate a ...
Josep Carreras Leukaemia Research Institute B-ALL is the most common paediatric cancer and, over the years and thanks to a very effective treatment based on glucocorticoids, its 5-year survival rates ...
Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR). This essential protein ...
Narrative Review Assesses Current Treatment Challenges and the Evolving Classic Congenital Adrenal Hyperplasia (CAH) Therapeutic Landscape Non-Glucocorticoid (GC) Mechanisms for Treatment of CAH Could ...
Glucocorticoid receptors are found intracellularly in almost all tissues. Glucocorticoids enter cells through passive diffusion and form a complex with a receptor protein. This complex then undergoes ...
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