This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Myosin Therapeutics, a clinical-stage biotechnology company advancing first-in-class therapies targeting molecular motor proteins, announced the publication of two major papers in the journal Cell ...

Titin wraps around the myosin filaments that compose individual muscle fibers, and when muscle fibers contract, a part of titin becomes exposed that’s otherwise inaccessible.

Myosin chaperones are pivotal in ensuring proper muscle development by guiding the folding, assembly, and quality control of myosin motor proteins. These specialised proteins, such as UNC-45 ...

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

Title: EDG-5506 Targets Fast Skeletal Myosin to Protect Dystrophic Muscle and Reduce Muscle Damage Biomarkers in a Phase 1 Trial in Becker Muscular Dystrophy (BMD) (P.124) Date: Friday, October 14 ...

You’re doing the work, you’re feeling the burn, but how long does it actually take to build muscle?Building muscle isn’t just a matter of showing up and working out however and whenever you want.

This specificity was further underscored by F10's differential impact on ATPase activity across various myosin isoforms in different muscle types, highlighting its specificity for cardiac myosin.

Recently, our lab discovered that non-muscle myosin IIA (NMIIA) motors interact with the spectrin-actin network to maintain RBC biconcave shape and deformability. We are studying nanoscale lattice ...

Cytokinetics Inc. has disclosed fast skeletal muscle myosin inhibitors reported to be useful for the treatment of Becker muscular dystrophy, Duchenne muscular dystrophy, facioscapulohumeral muscular ...