The 49ers vs. Buccaneers game kicks off at 4:25 p.m. ET/1:25 p.m. PT on Sunday, Oct. 12, 2025. The Week 6 game between the 49ers and the Buccaneers will air in select markets on CBS, which means it'll also stream live in those markets on Paramount+. You can also tune in on mobile devices with NFL+.

The 49ers’ defense is coached by former Jets head coach Robert Saleh, who is known throughout NFL circles as one of the brightest defensive minds in the game. Saleh, a native of Michigan, has been linked to college football head coaching jobs recently during an NFL season that is still in full swing.

Week 7 will conclude with yet another Monday Night Football doubleheader. The Detroit Lions (4-2) will host the Tampa Bay Buccaneers (5-1) and the Seattle Seahawks (4-2) will host the Houston Texans (2-3). The Buffalo Bills (4-2) and Baltimore Ravens (1-5) are on a bye in Week 7, riding two- and four-game losing streaks, respectively.

Week 8's injury report has confirmed several key absences, impacting fantasy lineups and game strategies amid six byes

Once again, there was a lot to like out of the NFC West this week. The Los Angeles Rams continue to be one of the best teams in the league, while the San Francisco 49ers had an impressive win. And let’s not forget about the cheat code that is Jaxon Smith-Njigba and his chemistry

The 49ers waived a tight end to make room for George Kittle to return from injured reserve. It feels like the San Francisco 49ers are hit with the injury bug every NFL season — and this one is no different.

It's the Atlanta Falcons vs San Francisco 49ers tonight on Sunday Night Football. Live coverage begins at 7 PM ET.