Oligodendrocytes (the cells that produce myelin) and nerve fibers are also destroyed. 1–4 Most patients with multiple sclerosis have an initial relapsing–remitting course for 5 to 15 years ...

Oligodendrocytes grown in thyroid hormone did not stain positively for NG2 or A2B5 (Figure 5A,B) indicating that these oligodendrocytes were mature. (Enlarge Image) Oligodendrocyte morphology .

Now, in a study published in The Journal of Neuroscience, researchers tracked oligodendrocytes as they aged and found that mature oligodendrocytes survived longer following DNA damage and underwent a ...

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new ...

Three recent papers challenge that assumption, identifying another, unexpected source—oligodendrocytes. In the September Nature Neuroscience, scientists led by Klaus-Armin Nave at the Max Planck ...

These differences suggest the oligodendrocytes are functioning differently in the brains of people with MS, which might be key to understanding how disease progresses, the researchers say. Professor ...

Chemicals from 2 groups had an adverse effect on oligodendrocytes. Organophosphate flame retardants, which are commonly found in electronics and furniture, inhibited the generation of ...

An experimental medication boosted motor function in mice and primate models of multiple sclerosis by repairing the myelin ...

Oligodendrocytes under Immune Attack Actively Harm Axons. The scientists could also identify a mechanism how oligodendrocytes attacked by T cells harm their axonal partners.

“Loss of oligodendrocytes underlies multiple sclerosis and other neurological diseases,” said the study’s principal investigator, Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of ...

The new therapy, called PIPE-307, targets an elusive receptor on certain cells in the brain that prompts them to mature into myelin-producing oligodendrocytes. Once the receptor is blocked, the ...