Mea6 is involved in the transport of different lipids from the ER to the Golgi apparatus, and plays an essential role in the formation and/or maintenance of white matter.

It may be that the demands on the ER are especially high in astrocytes and/or oligodendrocytes ... [45] Vanishing white matter (VWM) is caused by mutations in the genes for eIF2B, an important ...

White matter ... of the white matter of the brain. Autoimmunity in multiple sclerosis (MS) is generally considered to be directed against components of myelin or oligodendrocytes.

Vanishing white matter (VWM) is an inherited and often ... The myelinating cells, oligodendrocytes, are affected in VWM. Initial studies suggested that VWM mutations decreased eIF2B's activity.