Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord.

Transplantation of oligodendrocyte-producing cells into lesions of multiple sclerosis is being considered as a therapeutic strategy to enhance remyelination. 26 It remains to be determined ...

Oligodendrocyte progenitor cells repair damaged spine in humans in clinical trial in a breakthrough for regenerative medicine October 15, 2017 December 27, 2016 by Brian Wang Asterias Biotherapeutics ...

Oligodendrocyte ablation in adult mice affects nociception. We achieved inducible ablation of oligodendrocytes in adult mice by mating mice expressing the DTR in a conditional locus, which enables ...

Uncover the mechanisms behind brain tumour spread. New research sheds light on glioblastoma infiltration of normal brain ...

The research team in National Institute for Physiological Sciences (Okazaki, Aichi, Japan) developed a novel method for labeling a single oligodendrocyte and revealed characteristics of selective ...

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oligodendrocyte progenitor cells. Brain Fluid from Youngsters Gives Old Mice a Memory Boost . Dan Robitzski | | 3 min read. A growth factor found in the cerebrospinal fluid of young mice triggered the ...

This cycle of oligodendrocyte degeneration and renewal is responsible for the relapses and remissions of multiple sclerosis, noted senior author Dwight Bergles. He and Rothstein previously reported ...

Oligodendrocyte progenitor cells are derived from stem cells. During development, production starts in the spinal cord where sonic hedgehog (SHH) signaling molecule controls transcription of ...

In MS lesions, CSPGs accumulate as constituents of demyelinating plaques, which inhibit the migration and differentiation of oligodendrocyte precursor cells and remyelination.

There is loss of oligodendrocytes and alteration of oligodendrocyte subtypes in CTE that might provide new targets for prevention and therapies," said corresponding author Ann McKee, MD, chief of ...