As with systemic manifestations, the effects of WM on the nervous system reflect the rheological properties of the IgM paraprotein, nonspecific IgM deposition, antibody-mediated damage to nerves ...

Despite extensive imaging and testing, the pathophysiology underlying this syndrome remains unclear. The presence of an IgG kappa paraprotein in all three patients tested may suggest a pathogenic ...

However, after 4 months off treatment, levels of IgG kappa paraprotein began to increase, as did her serum erythropoietin level. Retreatment with bortezomib has been difficult because of the ...

Paraprotein and absolute miRNA levels are plotted in Figure 5. These data show that miR-720 and miR-1308 are not correlated with paraprotein in the blood. However, ...

Sporadic late-onset nemaline myopathy with monoclonal paraprotein as a malignancy rather than disimmunity and treatment with chemotherapy-based approach.. JCO 38 , 8545-8545 (2020). DOI: ...

Non-secretory myeloma is a rare form of myeloma. In people with this form, myeloma cells do not release an abnormal protein called paraprotein, making it harder to diagnose than other types of ...

Each paraprotein is made up of: 2 long protein chains - these are also called heavy chains; 2 shorter protein chains – these are also called light chains; This is important because sometimes the ...

The presence of paraprotein is generally considered a defining feature of myeloma, although a small proportion of cases have no detectable paraprotein. This is known as non-secretory myeloma and is ...

The detection of this paraprotein has allowed the identification of an asymptomatic precursor that is known to precede MM, amyloidosis, or other lymphoproliferative disorders. 2-4 This gave rise to ...

Precancerous, or smoldering, multiple myeloma (SMM) is by definition an asymptomatic disease, and about 50% of those diagnosed with this precursor condition will develop full MM within 5 years. ...

Monoclonal gammopathy of undetermined significance is a common problem. About 4.2% of people aged 50 years or older have this condition, and its prevalence increases with age — almost 10% of men older ...

paraprotein in your blood that is more than 30 g/L, or in your urine that is more than 500mg in 24 hours or; a level of abnormal plasma cells in your bone marrow that is between 10% and 60%; no ...