Knowledge about an antibody’s epitope binding site is beneficial to researchers for many reasons, as recently described in a blog post by Callahan. For example, post-translational modifications ...

Proteins may have multiple names, isoforms, splice variants, and post-translational modifications. If your research depends on the antibody recognizing a specific portion of your target, note the ...

Monoclonal antibodies are considered the most rapidly growing ... strategies for deciphering the structure of proteoforms and the presence of post-translational modifications. In this webinar, our ...

“Progressing antibodies to the clinic is challenging ... contain important post-translational modifications required for function, and be directly translatable to the final manufactured product ...

with post-translational modifications, and carrying disease mutations. However, Burmer estimates that the number of highly validated antibodies (such as those used in diagnostics) is to fewer than ...

Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and post-translational modifications (PTMs). MALDI-IMS has been used to map histone ...

and post-translational modification detection from body fluids, cultured cells, and tissues. While highly efficient and robust, affinity proteomics is limited to well- characterized proteins with ...

"Phosphorylation is a key mechanism for regulating protein activity and signaling pathways across the entire range of ...

Several steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-translational modification of a protein. Gene regulation gives the ...

Proteins are immobilized on a solid surface, such as a glass slide or membrane, and then probed with labeled antibodies or other ligands to detect specific protein-protein interactions or ...