DIAD is caused by mutations in three genes: amyloid precursor protein (APP), presenilin-1 (PSEN1) or presenilin-2 (PSEN2). The overwhelming majority of people with DIAD only carry one of these ...

The paper T. Liu et al., “The amyloid precursor protein is a conserved Wnt receptor,” eLife, 10:e69199, 2021. Amyloid precursor protein, which generates amyloid-β when broken down, has long been ...

These aspects, as well as the role of metal–Aβ interactions, appear to be an obligatory step in the pathogenic events leading to AD (Figure 1 ... years. Amyloid-β (Aβ) precursor protein ...

We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid ... 1-42 fragments and the C-terminal fragment. Alternatively, at the cell surface, beta-amyloid precursor protein ...