Open-access databases such as the European Nucleotide Archive (ENA) contain more than 2.4 million bacterial genomes, and this number continues to grow rapidly. Until now, searching these vast ...

Alignment of DNA and protein sequences is a basic tool in the study of evolutionary, structural and functional relationship among macromolecules. Present sequence alignment methods are somewhat ...

Over the last 10 years, breakthroughs in understanding the genetic instructions passed from parent to offspring have put researchers closer than ever before to efficiently decoding DNA with 100% ...

One of the curious properties of mathematics is its beauty. But exactly what mathematicians mean by beauty is hard to capture. Perhaps the most famous example is Euler’s relation, e iπ + 1 = 0, which ...

Algorithms consist of instructions that are carried out (performed) one after another. It is crucial that the steps in an algorithm are performed in the right order - otherwise the algorithm will not ...

The evolution of DNA sequences can be described by discrete state continuous time Markov processes on a phylogenetic tree. We consider neighbor-dependent evolutionary models where the instantaneous ...

Scientists have developed a way of finding optimal peptide sequences: using a machine-learning algorithm as a collaborator. The algorithm analyzes experimental data and offers suggestions on the next ...

Baidu Inc.’s preclinical studies showed the mRNA vaccine sequences for COVID-19 designed using its Lineardesign algorithm outperformed the benchmark sequences designed by traditional algorithms in ...