G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets ... G protein–coupled receptors (GPCRs) remains obscure.

(Cited in 50 papers) The finding: In 2005, while screening for G protein-independent arrestin signaling on the widely studied ERK pathway, Robert Lefkowitz's group at Duke University showed that ...