The screw conveyor has an extensive history. Archimedes (ca. 212 BC) invented the first screw conveyor, and his design is still used today for irrigation and grain transfer. Screw conveyors became ...

Pharmaceutical manufacturing requires defining quality target product profiles and critical quality attributes (CQAs) to ensure desired product quality. Process development identifies critical process ...

Biopharmaceuticals are complex molecules produced by living cells, with strict control of bioprocessing being required to ensure the production of high-quality therapeutic proteins. Deviations in ...

The past decade has seen unparalleled growth in the field of cell therapy, which uses cells as therapeutic agents to treat and cure disease. Although the first transplants of blood stem cells date ...

Process analytical technology (PAT), a quality assurance program for the pharmaceutical industry developed by the US Food and Drug Administration, enables pharmaceutical manufacturers to control ...

In today’s highly regulated environment for drug development and manufacturing, new challenges have emerged from internal pressures to reduce costs by eliminating waste in the development process, ...

Aim: To demonstrate the potential of in-line nanoparticle size measurements using the NanoFlowSizer (NFS) as a PAT method. To achieve real-time process control by establishing automated regulation of ...

GEN: Can you speak to your experiences with scale-down screening model systems? Do you have a preference? Sieck: The best screening model depends on specific needs. An ideal small-scale model should ...