Series trends: In 2003, as a 6-point underdog at Illinois, Northwestern scored a 45-43 upset, keeping the Illini from qualifying for a bowl game. The two years before that, the Illini won big – 41-3 in 2022 and 47-14 in 2021 – covering easily as the favorites. All three games went over.

It is a Big Ten rivalry as we continue our college football odds series with an Illinois-Northwestern prediction and pick.