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See winning numbers for Powerball, Pick 3 on Oct. 22, 2025

Powerball winning numbers for $321 million jackpot drawing on Wednesday, Oct. 22

The Powerball jackpot for Wednesday, Oct. 22 is an estimated $321 million after no one took home the top prize on Monday, Oct. 20.

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Wisconsin Lottery Powerball, Pick 3 results for Oct. 22, 2025

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Powerball winning numbers, results for Wednesday, October 22, 2025: No jackpot winner

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Maine Lottery results: See winning numbers for Powerball, Pick 3 on Oct. 22, 2025

The Maine Lottery offers several games for those aiming to win big.

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Mass Lottery Powerball, Lucky For Life winning numbers for Oct. 22, 2025

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Arkansas Lottery Powerball, Cash 3 winning numbers for Oct. 22, 2025

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Connecticut Lottery player wins $1M Powerball prize before birthday, Waterbury player wins $50K

A Connecticut Lottery player from Waterbury also claimed a $50,000 prize as the Powerball jackpot continues to grow.

Powerball winning numbers for Wednesday, Oct. 22, 2025; jackpot $320 million

CLEVELAND, Ohio — The Wednesday, Oct. 22, 2025, Powerball drawing has selected the winning numbers for a jackpot estimated at $320 million. The numbers are 18-37-52-54-60 Powerball 12 Power Play 2x. The Classic Lotto numbers are 4-11-24-25-26-28 Kicker 301195. The jackpot is $9.6 million for the Saturday, Oct. 25 drawing.

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The Lotto Matrix: Mega, Powerball On Growth Spurts

Michigan again holds steady at No. 3, taking the final podium spot with a $16.55 million jackpot available Saturday night. California returns to the list in fourth at $10 million, and at $9.6 million Ohio has fended off Arizona ‘s The Pick ($9.4 million) to complete the top five.

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Weekend jackpot drawings to reach over $1 billion

Lottery players across the nation are eagerly anticipating this weekend’s massive jackpot drawings, as the Mega Millions and Powerball jackpots will be over $1 billion.