Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

tRNA is an important component of the biological synthesis of new proteins, as it carries a specific amino acid that will be incorporated to the protein through the ribosome machinery, as directed by ...

The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

Raghu R. Chivukula, MD, PhD, a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the ...

An engineered enzyme is at the center of a new method to visualize molecular details in human cells, and how these molecules change in cancerous versus benign cells, report Boston College researchers ...

A team of researchers from Mass General Brigham led by Raghu Chivukla, MD, PhD released a new study linking protein aggregation to altered RNA processing in genetic forms of neurodegeneration.

The fruit fly lacks the tRNA nuclear export receptor Exportin-t, which only exports end-processed tRNAs to the cytoplasm to ensure the completion of the processing steps in the nucleus. The related ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...