Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation ...

Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...

Morphologic and genomic characterization of circulating tumor cells in patients with metastatic colorectal cancer treated with combinational treatment of andecaliximab, bevacizumab and chemotherapy.

The stimulation of the mitochondrial apoptotic pathway by gal-1 initiated ceramide release 21 and the requirement of AP-1 for ceramide-induced apoptosis 26 prompted us to investigate the role of the ...

A study led by Garvan researchers has uncovered why some breast cancers become resistant to treatment, potentially opening the door to more effective therapies for patients. Published today in the ...

Molecular pathways that influence cellular life-and-death decisions increasingly fall under the scientific spotlight. In 1996, researchers discovered that NF-kB is anti-apoptotic, which led to the ...

Association of immune-related genes to neutrophil-lymphocyte ratio (NLR) with survival of cetuximab treatment for metastatic colorectal cancer (mCRC): JACCRO CC-05/06AR.

Neurons, with their large cell bodies and extensive processes, depend on a delicately balanced intracellular transport machinery to keep in touch with their own outer reaches. Inequalities between ...