Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding ...

Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.

Experiments mapping individual neurons in the sensorimotor cortex of mice show that sharp transitions in functional properties can define cortical regions.

Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in ...

Disrupting left superior frontal sulcus selectively impaired perceptual but not value-based decisions, revealing segregated ...

Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and ...

Centralized migration accelerates adaptation and drives parallel evolution, emphasizing the key influence of spatial organization on evolutionary dynamics across systems from pathogen transmission to ...

Analyses of self-paced reading times reveal that linguistic prediction deteriorates under limited executive resources, with this resource sensitivity becoming markedly more pronounced with advancing ...

Conserved mast-cell activation, marked by elevated protease expression, aligns with progressive tuberculosis across human, macaque, and murine models.

An innovative and scalable proximity labelling method profiled proteins present in the Caenorhabditis elegans brain during learning, identifying known regulators as well as novel biological pathways.

A research team has developed a way to produce a subset of highly specialised brain neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury, laying foundations ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.