Gut

From IPMN to invasive pancreatic cancer: new spatial insights

Early detection and interception of pancreatic ductal adenocarcinoma (PDAC) remain the only realistic strategies to reduce ...
Gut

Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis

Primary biliary cholangitis (PBC) is a rare chronic autoimmune cholangiopathy that mainly affects middle-aged women, ...
Gut

Real-world evidence supports earlier treatment in HBeAg-positive but not HBeAg-negative chronic hepatitis B virus infection

In chronic hepatitis B virus (HBV) infection, the central debate remains whom and when to treat. The 2025 European Association for the Study of the Liver (EASL) Clinical Practice Guidelines (CPGs)1 ...
Gut

Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study

Background Post-infection disorders of gut-brain interaction (PI-DGBI) are a subset of chronic gastrointestinal disorders triggered by acute infectious gastroenteritis. These conditions impose a ...
gut.bmj

Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression

Objective Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which contributes to therapeutic resistance and tumour recurrence. We previously identified Prominin-1 (PROM1)/CD133 as an ...
gut.bmj

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

2 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK 3 Institute of Applied Health Research, University of Birmingham, Birmingham, UK Correspondence to Dr Palak J ...
gut.bmj

Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies

Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, carrying a greater risk of developing cirrhosis and its complications. For decades, pegylated interferon alpha (PegIFN-α) has ...
gut.bmj

Microbial determinants of effective donors in faecal microbiota transplantation for UC

Objective Faecal microbiota transplantation (FMT) has variable efficacy in treating UC. Recently, oral lyophilised FMT was found to induce remission in patients with UC, with one donor having 100% ...
gut.bmj

Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ ...

Objective Gastric cancer (GC) ranks fifth in incidence and fourth for mortality worldwide. The response to immune checkpoint blockade (ICB) therapy in GC is heterogeneous due to tumour-intrinsic and ...
gut.bmj

Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies

Objective The association between the regular use of proton pump inhibitors (PPIs) and the risk of type 2 diabetes remains unclear, although a recent randomised controlled trial showed a trend towards ...
gut.bmj

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

1 Department of Gastroenterology and Hepatology, UMC Utrecht, The Netherlands 2 Department of Metabolic and Endocrine Diseases, UMC Utrecht and Netherlands Metabolomics Centre, The Netherlands 3 ...
gut.bmj

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder

Correspondence to Professor Siew C Ng, Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong; siewchienng{at}cuhk.edu.hk; Dr Ruth Chan, Applied Biology and Chemical ...