通过整合单细胞TCR测序（scTCR-seq）和高通量测序（HTS）技术，研究人员系统分析了人类、小鼠、恒河猴、蝙蝠和牛等五种哺乳动物胸腺及外周组织的TRB CDR3库。令人惊讶的是，在所有物种中都 ...

Lete-cel is a milestone adoptive T-cell therapy approach in sarcomas, and it is a unique product because of the enhanced affinity achieved by the amino acid substitutions in CDR3 α and CDR2 β regions.

相比之下，H-mab 的碱性电荷变体与重链互补决定区 3（CDR3）中 D 99 - 琥珀酰亚胺的形成有关，显著损害了结合和酶抑制活性。 本研究强调了 FF-IEF 在生物类似药和创新治疗药物研发流程中不可 ...

而后将该结合短肽作为CDR3，填入纳米抗体，CDR1和CDR2继续沿用原始序列（图3）。纳米抗体与抗原蛋白分子对接，从图2B中可以看到，纳米抗体占据了 ...

However, the TCR pairing types and CDR3 characteristics of these Treg cells are largely unknown. Through innovative analysis of scRNA+TCR-seq data, we discovered that 10.1% to 21.4% of dual TCR Treg ...

Tissue-specific patterns in TCR repertoire features, such as V-J gene recombination, complementarity-determining region 3 (CDR3) sequences, and motif distributions, were analyzed. Multi-layer machine ...

1 Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China 2 Ocean College, ...

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