The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at ...

Running back Christian McCaffrey says the 49ers are “hungry” to make a playoff push even with the defending NFC champions ...

Buffalo Bills linebacker Matt Milano is expected to see NFL action on Sunday for the first time since October 2023. The Bills have activated Milano ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

Highest snow accumulations expected east of Lake Ontario, where some isolated areas could get hit by up to 60 inches of snow.

Related: Bills Can Make History vs. 49ers on 'SNF' "Lots of things can happen between now and then, but right now he's ...

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

The Buffalo Bills will look to clinch the AFC East on Sunday with a win against the San Francisco 49ers in what's expected to ...

The lake-effect storm disrupted holiday plans and travel across the region. National Guard troops were dispatched in New York ...

The first snow is beginning to fall at Highmark Stadium ahead of the Buffalo Bills' Week 13 bout with the San Francisco 49ers ...

On Saturday, the San Francisco 49ers announced the following roster moves ahead of Sunday's snowy game in Buffalo against the ...