LX9851, discovered and developed by Lexicon, is a potent and selective oral small molecule inhibitor of Acyl-CoA Synthetase 5 (ACSL5) . ACSL5 plays a key role in the metabolic pathway which ...

Lexicon’s drug is an oral small molecule that blocks Acyl-CoA Synthetase 5, or ACSL5, a metabolic pathway that’s thought to be involved in energy expenditure and fat accumulation.

Novo Nordisk’s stock has remained stable on the news. LX9851 targets Acyl-CoA Synthetase 5 (ACSL5), an enzyme involved in fat metabolism and energy balance. Preclinical data presented at Obesity Week ...

P. I. Fields, R. V. Swanson, C. G. Haidaris, F. Heffron, Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastoma multiforme (GBM) is the most ...

Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China ...

We further show that the up-regulation of the SAM transmethylation pathway and the efficiency of the immune response also depend on the recycling of adenosine back to ATP by adenosine kinase and ...

The endocrine and sarcoma surgery section at Karolinska treats over a thousand patients with sarcoma and tumors and/or functional disorders in endocrine organs every year, in a multidisciplinary ...

Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling (ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of calcium homeostasis ...

Pituitary adenylate cyclase activating polypeptide (PACAP) is associated with Alzheimer’s disease (AD), but its age-related effects are unknown. We chose the rhesus macaque due to its closeness to ...