Amyloid Precursor Protein’s Roles Outside of Alzheimer’s Disease Amyloid ... factors—Huntington’s is always explained by a mutation in the huntingtin gene. But it’s like Alzheimer’s and Parkinson’s in ...

called amyloid precursor protein, into smaller pieces, one of which is amyloid beta. Previous work by the research team had ...

Researchers have dosed the first participant in a clinical trial of an investigational medicine designed to lower the amount of amyloid precursor ... that carries a gene pivotal to causing Alzheimer's ...

We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid precursor protein (APP), and amyloid-beta 40 and amyloid-beta 42 peptides in children with and without autism.

Goldstein and his colleagues studied the role of amyloid precursor protein (APP), which gives rise to the abnormal ... To complement the mouse studies, the researchers studied the effects of various ...

Background: The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights ...

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein ... shown to achieve gene silencing in the ...

A micrograph showing inflammatory responses in the cortex of the new model mouse. Alzheimer's disease patients and mouse ...

As the gene silencing process is catalytic ... The investigational RNAi therapeutic targets mutant versions of amyloid precursor protein (APP), which are closely associated with familial ...

Genetics researchers studied eFAD families to discover the three known genes that cause familial AD: amyloid precursor protein (APP), presenilin-1 (PS1 ... Tests can determine which gene is at fauly ...