We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid precursor protein (APP), and amyloid-beta 40 and amyloid-beta 42 peptides in children with and without autism.

Researchers hope to launch human clinical trials in their quest for a vaccine to prevent the buildup of pathological tau after demonstrating that this vaccine generated a robust immune response in ...

University of New Mexico Health Sciences researchers hope to launch human clinical trials in their quest for a vaccine to ...

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein (APP) in the central nervous system – was ...

So that an exact blueprint for each protein can reach the production site in the cell, the information from the genome must be copied into messenger RNA, or mRNA for short. First, a precursor mRNA ...

So that an exact blueprint for each protein can reach the production site in the cell, the information from the genome must be copied into messenger RNA, or mRNA for short. First, a precursor mRNA ...

CD47 is found to play a pivotal role in this immunosuppression by inducing the production of amyloid-β (Aβ), which interacts with ... B-cell numbers in CLP mice (Appendix Fig. S20). The mRNA levels of ...

This important work advances our understanding of the aging trajectory and heterogeneity of hippocampal microglia. The authors provide an in-depth characterization of microglia in young and old mice ...

We investigated the temporal distribution of the p53-immunoreactive protein in conjunction with cellular damage and the expression of the p53 mRNA after focal cerebral ischemia in rats. Male Wistar ...