Amyloid precursor protein (APP) secretase plays a pivotal role in the processing of APP since its activity precludes the formation of amyloid peptide in Alzheimer's Disease. The identity and the ...

Researchers at Curtin University in Perth, Australia, have discovered that leakage from blood into the brain of fat-carrying particles transporting toxic proteins are a possible cause of Alzheimer's ...

A key protein must be cut to create amyloid beta. Groundbreaking work identifies the 'lipid raft' in nerve cells where this process occurs, which could offer new targets for drug therapy. In a major ...

PARIS, February 26 /PRNewswire-FirstCall/ -- ExonHit Therapeutics (Alternext: ALEHT) is pleased to announce that clinical testing of EHT 0202, its lead compound in ...

PHOENIX, Ariz. -- April 13, 2021 -- Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ...

Researchers have identified a new drug that could prevent AD by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques. Amyloid plaques are pathological hallmarks of ...

Scientists have developed a new drug that modulates a key enzyme responsible for forming the amyloid plaques linked to the onset of Alzheimer’s disease. (CN) — Researchers unveiled new evidence that a ...

While clinicians commonly gauge a person's Alzheimer’s disease risk by the amount of Aβ42 in their cerebrospinal fluid, it is unclear exactly what shorter peptide fragments mean in this regard.

This is a preview. Log in through your library . Abstract The γ-secretase complex, consisting of presenilin, nicastrin, presenilin enhancer-2 (PEN-2), and anterior pharynx defective-1 (APH-1) cleaves ...