Most synapses form on small, specialized postsynaptic structures known as dendritic spines1. The influx of Ca2+ ions into such spines—through synaptic receptors and voltage-sensitive Ca2 ...

Recent scientific evidence suggests consciousness is more than just a function of the brain and three theories have emerged ...

A key goal in neuroscience is to explain how the operations of a neuron emerge from sets of active channels with specific dendritic distributions. If general principles can be identified for these ...

A new study published in Science has found that neurons in the brain do not follow a single strategy when learning. Instead, different parts of the same neuron—its upper and lower branches—adjust ...

PATIENTS AND METHODS: All patients had hormone-refractory prostate cancer. Dendritic-cell precursors were harvested by leukapheresis in weeks 0, 4, 8, and 24, loaded ex vivo with antigen for 2 days, ...

Learning Objectives: 1. Identify the key roles of dendritic cells in cancer immunotherapy, including their use as antigen-loaded vaccines and intratumoral adjuvants. 2. Explain the strategies used to ...