eLife

Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...
Nature

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

The ubiquitin/proteasome-dependent proteolytic pathway is an attractive target for therapeutics because of its critical involvement in cell cycle progression and antigen presentation. However, ...
IEEE

Green Fluorescent Protein and Phase Contrast Image Fusion via Dual Attention Residual Network

Abstract: In cell and molecular biology, the green fluorescent protein (GFP) image contains functional information related to the molecular distribution of living cells while the phase contrast image ...
eLife

A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

This study represents a valuable addition to the catalog of mitochondrial proteins. With the use of methodology based on the bi-genomic split-GFP technology, the authors generate convincing data, ...
gut.bmj

Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

Objective Mutations in presenilin genes are the major cause of Alzheimer’s disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins ...