Nature

Presenilin mutants subvert chaperone function

Mutant presenilin proteins, known to promote the development of Alzheimer’s disease through increased generation of Aβ 42 peptides, appear to compound this insult by downregulating the signalling ...
Nature

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(c) Fluorescence microscopy of Zbtb46-GFP, CD4, B220 and β-catenin, and of staining with the DNA-intercalating dye DAPI, in sections of small intestine (top) and colon (bottom) from chimeras (n = 5) ...
C&EN

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States Center for Neurologic Diseases, Brigham and ...
C&EN

Overexpression of Human CRB1 or Related Isoforms, CRB2 and CRB3, Does Not Regulate the Human Presenilin Complex in Culture Cells†

Centre for Research in Neurodegenerative Diseases, 6 Queen's Park Crescent West, Toronto, Ontario M5S 3H2, Canada, The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick ...
ALZFORUM

PSEN-1

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...