This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...
To conclude, our results show that eGFP expression impairs actin-myosin interactions, thereby causing excitation-contraction uncoupling and impaired contractile function of muscle cells. This adverse ...
The ubiquitin/proteasome-dependent proteolytic pathway is an attractive target for therapeutics because of its critical involvement in cell cycle progression and antigen presentation. However, ...
At Conn, we don’t just ask “What’s your major?” We ask you to make connections between your education and your interests—to combine your learning and your likes into a personalized experience that ...
Division of Psychiatry and Behavioral Proteomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan, and Adolf Butenandt Institute, Department of ...
Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200 F, 3001 Heverlee, Belgium, Department of Agriculture, Katholieke Universiteit Leuven, Kardinaal Mercierlaan, 3001 Heverlee, ...
Objective Mutations in presenilin genes are the major cause of Alzheimer’s disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins ...
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