From cognitive enhancement to mood support and increased energy levels, methylene blue has gained popularity for its potential physiological benefits. Originally developed as a dye, methylene blue ...

An expert in connective tissue disease–associated interstitial lung disease described best approaches for rheumatologists to ...

The nitric oxide-independent soluble guanylate cyclase activator ataciguat continued to show promise for slowing the progression of fibrocalcific aortic valve stenosis in phase I and II studies.

Aortic valve stenosis (AVS) is a significant health concern affecting over 1.5 million Americans and millions more globally. Researchers at Mayo Clinic are exploring the use of a new drug ...

Time stops. Blame the umami taste of glutamate, which in caviar is enhanced by inosinate and guanylate for a triple whammy, and under whose influence I completely forget the price I have paid.

After a quiet few years Merck has returned to the category with soluble guanylate cyclase (sGC) stimulators Adempas (riociguat) and Verquvo (vericiguat) – partnered with Bayer – for PAH and ...

Safety of use during pregnancy or breastfeeding is uncertain. These drugs also act to increase intestinal fluid and intestinal movement by targeting receptors called guanylate cyclase-C (GC-C) ...

Adempas (riociguat) is the only drug in its class of soluble guanylate cyclase (sGC) stimulators. The drug is FDA-approved to treat PAH, more specifically, to improve tolerance for activity, reduce ...

Guanylate-binding protein 11; GO, Gene ontology; Igf2bp, Insulin-like growth factor 2 mRNA binding protein; KEGG, Kyoto Encyclopedia of Genes and Genomes; LOF, Loss-of-function; LPS, ...