"The cell apparently requires methylation at H3K9 and a yet-unknown chromatin or lamina protein by Prdm3 and Prdm16 for heterochromatin to be stable. As with other methyltransferases, ...

The research group, led by Thomas Jenuwein, describes two novel enzymes, Prdm3 and Prdm16, which attach a methyl group to a particular packaging protein of the DNA.

Earthquake in the cell Scientists discover how a modification of the nuclear lamina maintains nuclear shape Date: October 1, 2019 Source: Max Planck Institute of Immunobiology and Epigenetics ...

Kidney cells from those mice showed signs of nuclear membrane and chromatin breakdown. The cells had less nuclear lamina protein lamin B1, inner nuclear membrane protein lamin B receptor, and ...

Top: Micronuclei containing large chromosomes exhibit more Lamin B1 protein (blue) and delayed rupture. Middle: Micronuclei containing small, gene dense chromosomes exhibit delayed lamina ...

“The centromere distribution for non-Rabl configuration is regulated independently by the CII-LINC complex and a nuclear lamina protein known as CROWDED NUCLEI (CRWN),” explained Sachihiro Matsunaga ...

The genetic material of each mammalian cell is safeguarded within the nucleus. In healthy organisms, the usually round-shaped nucleus gets its stability from the nuclear envelope and the nuclear ...

Heterochromatin must be associated with this layer of lamina proteins at the inner nuclear membrane. “The cell apparently requires methylation at H3K9 and a yet-unknown chromatin or lamina protein by ...