Multiple myeloma is the second most common type of blood cancer, ... There are also several precancerous conditions that can sometimes lead to multiple myeloma. 1. Light Chain Myeloma.

If the ratio of the two types of free light chains is out of balance, it’s a sign of multiple myeloma. Myeloma cells. If your doctor tests your bone marrow, they’ll look for myeloma cells there.

For decades, the diagnosis of multiple myeloma required evidence of end-organ damage characterized by myeloma-defining events ...

Serum free light chain assay test: Normally, the light chains kappa and lambda have about equal numbers of each in the blood. If one is higher than the other, however, it can be a sign of myeloma.

Other symptoms of multiple myeloma include the following: Anemia: The overgrowth of myeloma cells in the bone marrow ...

Amyloidosis is a condition associated with multiple myeloma. In amyloidosis, the abnormal plasma cells create many light-chain proteins that can form amyloid deposits.

Monoclonal free light chains (FLCs) frequently cause rapidly progressive renal failure in patients with multiple myeloma. Immunoassays which provide quantitative measurement of FLCs in serum, have ...

AbbVie has entered into a $700 million licensing agreement with IGI Therapeutics to co-develop ISB 2001, a promising ...

Survival in multiple myeloma has almost tripled since the mid-1990s, ... In the patient presenting with renal failure, for instance, light chain cast nephropathy is a myeloma-defining event.

Conoley, A. J., et al. (2025). Therapy-related B-lymphoblastic Leukemia Following Treatment for Multiple Myeloma with Unusual Surface Light Chain Expression: A Case Report.

Discussion. The purpose of this study was to assess serum free light chain immunoassays as an aid in the diagnosis of multiple myeloma in patients with severe renal failure.