His research shows molecular changes in brain cells when a person develops multiple sclerosis (MS). But it is still unclear ...

An experimental medication boosted motor function in mice and primate models of multiple sclerosis by repairing the myelin ...

Tau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program. Brain Research, 1850, 149419.

Three recent papers challenge that assumption, identifying another, unexpected source—oligodendrocytes. In the September Nature Neuroscience, scientists led by Klaus-Armin Nave at the Max Planck ...

Oligodendrocytes also perform fatty acid (FA) β-oxidation in mitochondria and peroxisomes, using FAs for energy or synthesis. Reduced glucose levels affect FA metabolism and myelin turnover, ...

Alzheimer's disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing. The protein amyloid beta, which occurs naturally in the brain, plays a ...

The new therapy, called PIPE-307, targets an elusive receptor on certain cells in the brain that prompts them to mature into myelin-producing oligodendrocytes. Once the receptor is blocked, the ...

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new ...

Scientist captures images of human oligodendrocytes in a dish (stained green), which produce the protein implicated in causing Alzheimer's disease. [Francesca Lam (CC-BY 4.0, ...

And they found the quaternary ammonium compounds specifically killed oligodendrocytes but not the other cell types. The researchers also fed the chemicals to young mice for 10 days.

Chemicals from 2 groups had an adverse effect on oligodendrocytes. Organophosphate flame retardants, which are commonly found in electronics and furniture, inhibited the generation of ...