Tau is an intrinsically disordered protein (IDP) implicated in Alzheimer’s disease. Recently, tau proteins were discovered to be able to catalyze self-acetylation, which may promote its pathological ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, 3D ...

Tau aggregates were also subsequently found to use macropinocytosis to enter cells in different studies (Holmes et al, 2013; Sanders et al, 2014; Falcon et al, 2015). However, further progress has ...

News & Views Published: 18 March 2004 Cell biology The strain of being a prion Mick F. Tuite Nature 428, 265–267 (2004) Cite this article ...

Scientists have developed a synthetic fragment of tau protein, named jR2R3, which mimics prion-like behavior by misfolding and inducing other tau proteins to do the same, advancing our understanding ...

Amyloid-β (Aβ) and tau are the pathogenic hallmarks in Alzheimer’s disease (AD). Aβ oligomers are considered the actual toxic entities, and the toxicity relies on the presence of tau. Recently, Aβ ...

Betway Premiership clubs could soon be scrambling for Percy Tau’s signature after he was released by Qatar SC on Thursday at the end of his contract. The Bafana Bafana international made to switch to ...

Prion diseases are ultimately fatal, so treatment for GSS is supportive, helping to manage symptoms and improve quality of life. Treatment may include occupational, speech, and physical therapies.