"Assembled tau associates with EVs in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau ...

Get Instant Summarized Text (Gist) A specific form of the tau protein, the 1N4R isoform, has been identified as a key factor in mediating the toxic effects of protein clumps in Alzheimer's disease ...

Hyperphosphorylated tau can impair synaptic function. The same kind of prion-like seeding and spreading may be how that pathological tau propagates into the neocortex in Alzheimer's disease.

Figure 1: Induced tau tangle in the brain of an ALZ17 mouse. “This is a very important study—this process of 'inducible assembly' has also been shown for α-synuclein, amyloid-β and prion ...

In some circumstances Aβ oligomers can become misfolded into prion-like species that are directly neurotoxic, propagate by causing new monomers to take on the same toxic form, and lead to tau ...