Here we describe a mouse Fc receptor, designated Fcα/μR, and its human homolog, that bind both IgM and IgA with intermediate or high affinity. Fcα/μR is constitutively expressed on the ...

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including social monogamy in prairie voles. How Oxtr regulates specific components of social attachment ...

Online-only Tables 1A and 1B display allele and genotype frequencies of polymorphisms genotyped in populations of at least 100 apparently healthy, unrelated individuals from similar ancestry.

In addition, CD32B is expressed by human and mouse B cells and functions as an inhibitory receptor that blocks antibody production (10). We did not observe 4A5 staining of canine B cells. Dogs also ...

By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

Study of 2.4 million participants reveals potential advantages for cardiometabolic and psychiatric conditions alongside increased risks of gastrointestinal and musculoskeletal issues Study ...

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Despite being a first-line treatment for adolescent depression and anxiety, antidepressant drugs appear to have questionable efficacy and carry an increased risk of adverse effects in this ...

Email: jonsimmons{at}doctors.org.uk AIM To determine if polymorphisms in the VDR gene are associated with susceptibility to IBD SUBJECTS European Caucasoids: 158 patients with ulcerative colitis, 245 ...

and extended serum half-life via interaction with neonatal Fc receptor. This review, therefore, focuses on the progress of Fc engineering in generating bispecific molecules and on the use of small ...

1 Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, UK 2 Developmental Origins of Health and Disease Division, MRC Epidemiology Resource Centre ...