James Cook has a toe injury that made him questionable for Monday night’s Buffalo Bills game against the New York Jets. It could be a big loss for the team if he misses the contest. But will he return in Week 6 against the Jets? Here’s what we know as the clock ticks down to kickoff.

Monday Night Football in Week 6 will feature an important AFC East matchup between the Buffalo Bills and New York Jets. The Bills will hope to have running back James Cook available as they are coming off of back-to-back losses.

Primary running back James Cook injured his toe late in the Week 5 road loss to the Houston Texans. After missing back-to-back practices, the Bills' RB1 participated in a limited capacity on Saturday.