Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are ...

Losses by South Florida and Memphis cleared out two playoff contenders and improved the Aztecs’ chances for an improbable run ...

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale ...

Police said the marine unit was responding to a call for service around 5:30 p.m. when they saw an unresponsive person in the ...

San Diego scores twice during the final eight minutes to beat Oregon State and win the conference championship.

The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) Sunday in Week 11. Kickoff from State Farm Stadium in ...

Mayor Daniel Lurie has enjoyed strong approval ratings this year, but residents were dismayed after he appointed a city ...

An affiliate of Hospitality Properties Trust owns the hotel. The conversion proposal is being led by Jay Shah, vice president ...

Four people were killed and five others were rescued after a boat allegedly carrying undocumented immigrants capsized near a ...

An 80-year-old man was convicted Thursday in the decades-old murder of a teenager who was found dead in a San Francisco park.

Emergency responders found survivors of Friday's incident on the beach and rescued another trapped beneath the vessel, ...