Background Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms underlying uncontrolled airway ...

Department of Experimental Pathology, Cardiothoracic Institute, Brompton Hospital, London S.W.3 Mucoid sputum showed a highly significant correlation between pourability grade and viscosity. The mean ...

2 Institute for Transport Studies, University of Leeds, Leeds, UK 3 Centre for Epidemiology & Biostatistics, University of Leeds, Leeds, UK Introduction Road traffic accidents (RTA) are known to peak ...

Background Community acquired pneumonia (CAP) is a leading cause of hospitalisation in older adults and is associated with greater likelihood of adverse outcomes. Given the ageing population and lack ...

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder in which the motile cilia are usually static or dyskinetic. The movement of mucus along the mucociliary escalator is impeded by ...

Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...

Correspondence to: Professor J A Wedzicha Royal Free and University College Medical School, London NW3 2PF, UK; j.a.wedzicha{at}medsch.ucl.ac.uk If you wish to reuse ...

Introduction Tezepelumab, a human monoclonal antibody targeting TSLP, inhibits T2 inflammation leading to a fall in both the blood eosinophil count (Eos) and fractional exhaled nitric oxide (FeNO) ...

Introduction With improving cancer outcomes, indeterminate pulmonary lesions following radically-treated cancer are increasingly common, posing a diagnostic challenge of underlying aetiology. Existing ...

12 Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada Correspondence to Dr Wan C Tan, UBC James Hogg Research Centre, Providence Heart+Lung Institute, University of ...

Environmental factors, here taken to include pollutants, lifestyle factors and behaviours, can play an important role in serious, chronic pathologies with large societal and economic costs, including ...

Background Asthma remains the most common chronic disease in children and the UK has some of the poorest asthma outcomes in Europe. The socio demographic inequalities contribute to severe asthma ...