San Francisco 49ers safety Talanoa Hufanga is poised to make his season debut on Sunday against the Los Angeles Rams.

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San Francisco 49ers running back Christian McCaffrey will practice on Wednesday, though he will once again be limited.

Football, they say, is a war of attrition. For the 49ers and the Rams, attrition has arrived with a capital A.The latest name ...

The San Francisco 49ers have provided new injury updates ahead of Thursday's practice, adding two more key players to the ...

Brock Purdy had reason to celebrate on Saturday after his Iowa State Cyclones edged out the Iowa Hawkeyes, 20-19. However, ...

The 49ers will face the Rams on Sunday, for the first time since first-ballot, Deion-Sanders-Upper-Room Hall of Famer Aaron ...

Broadcast and streaming information for the San Francisco 49ers Week 3 matchup against the Los Angeles Rams at ...

Derek Carr, Kyler Murray and C.J. Stroud are among the players making big moves in Nick Shook's QB Index rankings entering ...

The San Francisco 49ers followed up their turbulent offseason with an impressive 32-19 victory over the New York Jets.

The San Francisco 49ers will be missing two of their biggest playmakers when they visit SoFi Stadium on Sunday to face the ...

Explaining the factors that drive line movements in betting markets, helping you assess whether a change is an overreaction ...