Tissue-specific patterns in TCR repertoire features, such as V-J gene recombination, complementarity-determining region 3 (CDR3) sequences, and motif distributions, were analyzed. Multi-layer machine ...

通过整合单细胞TCR测序（scTCR-seq）和高通量测序（HTS）技术，研究人员系统分析了人类、小鼠、恒河猴、蝙蝠和牛等五种哺乳动物胸腺及外周组织的TRB CDR3库。令人惊讶的是，在所有物种中都 ...

S#2 亚型由定型的 IGHV3 - 21 衍生重排且第三互补决定区（CDR3）较短来定义，此前研究表明它与不良预后相关，患者首次治疗时间短，且化疗免疫疗法（CIT）对这部分患者效果不佳 。然而 ...

A defining feature of successful vaccination is the ability to induce long-lived antigen-specific memory cells. T follicular helper (Tfh) cells specialize in providing help to B cells in mounting ...

NGS provides several angles of analysis such as clonotype frequency, CDR3 diversity, CDR3 sequence analysis, V allele identification with a quantitative dimension, therefore requiring high-throughput ...