Early-stage lung adenocarcinoma alters DNA methylation, mRNA transcription, and protein expression in adjacent tissues, exhibiting either steep changes at the tumor boundaries or shallow changes ...
Introduction: The tumor microenvironment (TME) plays a crucial role in cancer progression, yet the interactions between tumor cells and stromal components, such as fibroblasts, remain poorly ...
p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of p300/CBP decreases the activity of ...
We ship a minimal, easy-to-run Napari project (plugin + example dataset) so readers can reproduce and interactively explore reconstructed 3D volumes: (a) Load pre-aligned histological cross-sections ...
Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...
The arms and heads of opossums (pictured here one day before birth) and other marsupials develop faster than their legs and back bodies. Short-tailed opossums aren’t exactly cute when they’re born.
Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in China. It has a high rate of postoperative recurrence and lacks prognostic markers. In this study, we ...
Yuk-Lap (Kevin) Yip, PhD, is a professor and the interim director of the Center for Data Sciences at Sanford Burnham Prebys, and the senior and corresponding author of the manuscript. In biology ...
Recent advances in high-throughput transcriptomics have revealed extensive gene expression changes during cerebral ischemia. However, the changes in 3-dimensional chromatin architecture and long-range ...
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