Lexicon’s drug is an oral small molecule that blocks Acyl-CoA Synthetase 5, or ACSL5, a metabolic pathway that’s thought to be involved in energy expenditure and fat accumulation.

LX9851, discovered and developed by Lexicon, is a potent and selective oral small molecule inhibitor of Acyl-CoA Synthetase 5 (ACSL5) . ACSL5 plays a key role in the metabolic pathway which ...

Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan Department of Chemistry, Institute of Pure and Applied Sciences, University ...

Macrophages are vital sentinels in innate immunity, and their functions cannot be performed without internal metabolic reprogramming. Mitochondrial dynamics, especially mitochondrial fusion and ...

Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan ...

P. I. Fields, R. V. Swanson, C. G. Haidaris, F. Heffron, Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad ...