C&EN1mon
Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria ...
C&EN1mon
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States ...
eLife4y
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian ...
eLife8y
The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis
In this study, we demonstrate that the mitochondrial acyl carrier protein (ACP), which has a well-known role in FASII, plays an unexpected and evolutionarily conserved role in FeS biogenesis. ACP is a ...